Cardiac Electrophysiology · Simulation · Research

Find the critical isthmus — in the circuit, and in the problem.

Clinical electrophysiology expertise and whole-heart simulation technology for the people building, studying, and teaching the field.

Advisory Device and clinical strategy from a practicing electrophysiologist
Simulation Four-chamber cardiac simulation with a full virtual EP lab
Research Digital twin modeling of arrhythmia substrate
Critical Isthmus Consulting
Ablation & Mapping Complex Arrhythmia Four-Chamber Simulation Digital Twin Modeling Physician Education

What we do

Four areas of work.

An experienced electrophysiologist at the table while decisions are still reversible — whether the question is a catheter design, a training gap, or a study endpoint that won't hold up to review.

01

Clinical & Technical Advisory

Practicing-EP perspective on catheter, mapping, and energy-delivery technology — brought in early enough to change the outcome rather than validate it after the fact.

  • Device and catheter design review
  • Advisory board participation
  • Workflow and human-factors assessment
  • Clinical landscape analysis
02

Physician Education

Case-based teaching built for how electrophysiology is actually practiced — from fellowship curricula to hands-on technology sessions.

  • Procedural education and case support
  • Hands-on technology demonstration sessions
  • Fellowship and CME curriculum design
  • Simulation-based training programs
03

Evidence & Study Support

Getting the science right before it goes to a journal, a regulator, or a payer — from endpoint selection to the sentence reviewers will stop on.

  • Protocol and endpoint design review
  • Data interpretation and analysis planning
  • Manuscript and abstract development
  • Peer-review and editorial perspective
04

Simulation & Computational Modeling

CardaxEP, our whole-heart simulation platform, supports training, technology demonstration, and computational research.

  • Simulation-based demonstration
  • Custom arrhythmia scenarios
  • Competency assessment content
  • Research collaboration
In active development

The platform

CardaxEP

Four-chamber cardiac simulation with a complete virtual electrophysiology laboratory around it. Atria, ventricles, and the conduction system in one model — with catheters, electrograms, pacing, and imaging that behave the way they do in the lab.

The gap between reading about reentry and seeing a circuit collapse under a well-placed lesion is enormous. CardaxEP is a place to close it — where fellows can be wrong safely, engineers can iterate quickly, and hypotheses can be tested before anyone touches a patient.

NEW / PROBABILISTIC CIRCUIT MODELING

From a case map
to potential circuits.

Drag voltage-map screenshots from a real case into CardaxEP. Initiate simulated flutter on the map, or use the probability engine to explore potential circuits across 10–1,000 or more runs. Compare circuit frequencies and proposed lines for interrupting them with minimal intervention in the model.

CIRCUIT FINDING / 81-SECOND WORKFLOW

Import. Initiate. Survey. Compare.

Recorded simulation, edited for time. Accelerated sequences are labeled. Open the video directly

ACTUAL MODEL OUTPUT
Press play to watch · 1× player speed
AVNRT, overdrive pacing from the right ventricle — surface ECG, multipolar, coronary sinus, His, high-density mapping and right ventricular channels live.

Under the hood

Modeled, not mimicked.

Nothing on screen is an animation, a lookup table, or a recorded waveform. Every electrogram, every surface lead, and every response to pacing is computed, beat by beat, from the same simulated tissue — so when the physiology changes, everything downstream changes with it.

That is the difference between a simulator and a picture of one.

Atria
Reaction–diffusion across a biatrial mesh with anisotropic conduction, ionic membrane models, and a two-layer wall where fibrillation needs one.
Ventricles
Volumetric, tetrahedral myocardium with a fiber field and endocardial-to-epicardial heterogeneity, running a published human ventricular action-potential model.
AV node
Dual pathways with decremental conduction, so nodal reentry, Wenckebach, and block arise from the node rather than a rule.
His–Purkinje
A Purkinje network with loops that conducts in both directions and takes part in ectopy and arrhythmia.
Electrograms
Unipolar potentials from the tissue’s own current sources; bipoles are their difference, filtered as a recording system filters them.
12-lead ECG
The same sources summed at the body surface: axis, intervals, R-wave progression, and PVC morphology follow from the activation sequence.
PVC origins
Twenty-five ventricular origins placed by anatomy, at a chosen depth through the wall — the 12-lead and the activation map follow from where the beat begins.
Mapping
Activation and voltage maps built from catheter electrograms, beat by beat, with the beat gating a clinical system uses.

Whole-heart physiology

Atrial, ventricular, and conduction-system activation simulated together, so atrioventricular relationships emerge rather than being scripted.

The full recording system

Surface ECG, multipolar, coronary sinus, His, high-density mapping and ventricular channels — read the same way you would in the lab.

Programmed stimulation

Drive trains, extrastimuli, burst pacing and entrainment from any electrode, with the physiology responding in kind.

Simulated intracardiac imaging

A steerable intracardiac echo module rendered from the same anatomy, for catheter manipulation and standard-view training.

Mapping and ablation

Build activation maps, place lesions, and watch the circuit respond — block, slow, reorganize, or terminate.

Tunable substrate

Tissue properties move from normal toward diseased, so a single anatomy yields many distinct cases.

Typical atrial flutter
Atrial fibrillation · high-density atria
VT case · ventricular activation
Watch the full case (56 seconds)

CardaxEP is an educational, research, and technology-demonstration platform. It is not a medical device and is not intended for diagnosis, treatment planning, or clinical decision-making.

Research

Toward the digital twin.

The same engine that powers training is being developed as a research tool: simulation informed by an individual patient's anatomy and electrophysiology, to ask what a specific substrate will do before it is ablated.

  • Patient-specific modeling Building simulations from clinical mapping and imaging data rather than a generic heart.
  • Mechanism and substrate Studying how reentrant circuits form, sustain, and fail in computational models.
  • Validation against the lab Comparing simulated behavior with clinical recordings to earn trust in the model.

Who we work with

Industry, academia, and education.

Medical device industry

Ablation, mapping, and imaging teams who want an electrophysiologist's perspective while decisions are still reversible.

Design input Advisory boards Tech demonstrations

Research collaborators

Academic and computational groups working on arrhythmia mechanisms, patient-specific modeling, and simulation validation.

Digital twins Computational EP Validation

Training programs

Fellowship directors and simulation centers building curricula with somewhere safe to make the mistakes that actually teach.

Simulation curricula Case libraries Assessment

Contact

Correspondence.

Most engagements are arranged through established institutional and industry channels. For general correspondence, research collaboration, or CardaxEP inquiries, use the form or write directly.

Please don't include patient-identifiable clinical information in this form.